Professor Florian Monnier, Ph.D.
Institut Universitaire de France IUF
Ecole Nationale Supérieure de Chimie de Montpellier ENSCM
Organic Chemistry for Life Sciences
Green Chemistry for Sustainable Development
Research Interests:
Green Chemistry/ Life Sciences
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Synthesis of Biomolecules by Hydrofunctionalization of unsaturated compounds (allenes, alkynes, alkenes)
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Hydroamination (C-N)
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Hydrocarbonation , Hydroacylation , Hydroarylation (C-C)
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Hydrocarboxylation , Hydroalkoxylation (C-O)
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Hydrophosphination (C-P)
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Hydrosulfonylation (C-S)
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Industrial technologies transferts in Life Sciences
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Collaboration with several industries
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Valorization of biosourced molecules by homogeneous catalysis
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Direct amination of phenols
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Functionalization of terpenes
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Modification of phenols
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Abundant metal-catalyzed cross-coupling reactions
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Ullmann-type reactions catalyzed by Cu for C-C, C-N, C-O bonds formation
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Chan-Lam reactions catalyzed by Cu
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Professor Florian Monnier, Ph.D.
Full Professor, Doctor in chemistry for LifeSciences
Institut Universitaire de France IUF
Ecole Nationale Supérieure de Chimie de Montpellier ENSCM
Academic Career
Since 2016 Full Professor organic chemistry for Life Sciences & Green Chemistry, ENSCM
2015-2020 Nominated member of the IUF (Institut Universitaire de France)
2012-2016 Associate Professor in organic chemistry for Green Chemistry, ENSCM.
July 2012 Tenure in organic/green chemistry, Université de Montpellier 2.
2005-2012 Assistant Professor in organic chemistry, ENSCM.
2004-2005 Medicinal chemistry Industrial Post-Doc, Servier, Université de Montpellier 2.
2003-2004 Research associate, Post-Doc, Université de Genève (Switzerland).
2000-2003 PhD in chemistry, Doctorat (With highest honors), Université de Rennes 1.
1999-2000 M.Sc. in molecular chemistry, (With honors), Université de Rennes 1.
Awards and Honors
2015 - IUF member (by nomination, Institut Universitaire de France)
2013 - Young Researcher Award, Research Fellowship Languedoc-Rousillon
2013 - Excellence Prize, Minister of Science, France
2012 - Elected member of scientific board of CNRS (National Center for Scientific Research)
2011 - Senator of labex CheMISyst. (2011-2012)
2008 - Excellence Prize, Minister of Science, France
publications & patents
2002-2021
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Regio-, Stereo- and Enantioselective α-Addition of Carbonyl Nucleophiles to
Allenamides Catalyzed by a Synergistic Copper/Enamine System
R. Blieck, S. Lemouzy, M. Taillefer*, F. Monnier*
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Easy Access to Allylic Sulfones Through Transition-Metal-Free Hydrosulfonylation
Of Allenes
L. Pagès, S. Lemouzy M. Taillefer,* F. Monnier*
J. Org. Chem, 2021, 86, 15695-15701
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Metal-Catalyzed Intermolecular Hydrofunctionalization of Allenes:
Easy Access to Allylic Structures via the Selective Formation of
C–N, C–C, and C–O Bonds
R. Blieck,* M. Taillefer,* F. Monnier*
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Synthesis of α-CF3-substituted E-dehydroornithine derivatives via
copper(I)-catalyzed hydroamination of allenes
A. N. Philippova, D. Vorobyeva, F. Monnier, S. N. Osipov
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Hydroarylation of N-Allenyl Derivatives Catalyzed by Copper
R. Abdine, L. Pagès, M. Taillefer*, F. Monnier*
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Copper-Catalyzed Hydrocarboxylation of N-Allenyl Derivatives
R. Blieck, M. Taillefer*, F. Monnier*
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Hydrogen-bond promoted metal-free hydroamination of alkynes
J. Bahri,N. Tanbouza, T. Ollevier,* M. Taillefer*, F. Monnier*
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Mild Temperature Amination of Aryl Iodides and Aryl Bromides with Aqueous
Ammonia in the Presence of CuBr and Pyridyldiketone Ligands
R. Abed Ali Abdine, G. Kurpik, A. Walczak, S. Abu A Aeash, A. R. Stefankiewicz,*
F. Monnier,* M. Taillefer*
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Copper-Catalyzed Hydrocarboxylation of Allenes
R. Blieck, M. Taillefer*, F. Monnier*
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Mild Temperature Copper-Catalyzed Amination of Aryl Halides with
Aqueous Ammonia in the Presence of Pyridyldiketone Ligands
R. Abed Ali Abdine, G. Kurpik, A. Walczak, S. Abu A Aeash, A. R. Stefankiewicz,*
F. Monnier,* M. Taillefer*
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Copper-Catalyzed Hydroamination of N-Allenyl Sulfonamides:
The Key Role of Ancillary Coordinating Groups.
R. Blieck, L. A. Perego,* I. Ciofini, L. Grimaud*, M. Taillefer,* F. Monnier*
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Regio- and Stereoselective Copper-Catalyzed Allylation of 1,3-Dicarbonyl
Compounds with Terminal Allenes.
R. Blieck, R. Abed Ali Abdine, M. Taillefer*, F. Monnier*
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Copper-Catalyzed Hydroamination of N-Allenylazoles:
Access to Amino-Substituted N-Vinylazoles.
L. A. Perego, R. Blieck, J. Michel, I. Ciofini,*, L. Grimaud*, M. Taillefer,* F. Monnier,*
Adv. Synth. Catal. 2017, 349, 4388
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Copper-Catalyzed Hydroamination of Allenes: from Mechanistic
Understanding to Methodology Development.
L. A. Perego, R. Blieck, A. Groué, F. Monnier,* M. Taillefer,* I. Ciofini,*, L. Grimaud*
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Copper-Catalyzed Sonogashira Reaction in Water.
Y. Liu, V. Blanchard, G. Danoun, Z. Zhang, A. Tlili, W. Zhang, F. Monnier,
A. Van Der Lee, J.Mao,* M. Taillefer*
ChemistrySelect 2017, 2, 11599.
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From Ruthenium to Copper: A la carte Tools for the Synthesis of Molecules of Interest.
F. Monnier* M. Taillefer
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Copper-Catalyzed Hydroamination of Terminal Allenes.
R. Blieck, J. Bahri, M. Taillefer*, F. Monnier*
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Copper-Catalyzed Hydroamination of Alkynes with Aliphatic Amines:
Regioselective Access to (1E,3E)-1,4-Disubstituted-1,3-dienes.
J. Bahri, B. Jamoussi, A. Van Der lee, M. Taillefer*, F. Monnier*
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Hydroamination of terminal alkynes with secondary amines catalyzed by copper:
regioselective access to amines.
J. Bahri, R. Blieck, B. Jamoussi, M. Taillefer*, F. Monnier*
Chem. Commun., 2015, 51, 11210.
E. Racine, F. Monnier,* J.-P. Vors, M. Taillefer*
Chem. Commun., 2013, 49, 7412-7414.
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Copper-Catalyzed C(aryl)-N bond formation.
F. Monnier,* M. Taillefer,*
Topics in Organometallic Chemistry, Vol. 46, 2013, 173-204.
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Process for creating carbon-carbon bonds using carbonyl compounds.
M.Taillefer, F. Monnier, A. Tlili, G. Danoun.
PCT Int. Appl. (2013), WO 2013 EP61697 20130606 ; FR20120055275 20120606.
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Direct Copper-Catalyzed α-Arylation of Benzyl Phenyl Ketones with Aryl iodides:
Route towards Tamoxifen.
G. Danoun, A. Tlili, F. Monnier, M. Taillefer*
Angew. Chem. Int. Ed., 2012, 51, 12815-12819.
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Selective One-pot Synthesis of Symmetrical and Unsymmetrical Di- and
Triarylamines with a Ligandless Copper Catalytic System.
A. Tlili, F. Monnier,* M. Taillefer*
Chem. Commun., 2012, 48, 6408-6410.
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A simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides.
E. Racine, F. Monnier,* J.-P. Vors, M. Taillefer*
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Ruthenium-Catalysed Synthesis of Fluorinated Bicyclic Amino Esters via
Tandem Carbene Addition/Cyclopropanation of Enynes.
M. Eckert, S. Moulin, F. Monnier, I. D. Titanyuk, S. N. Osipov, T. Roisnel,
S. Dérien,* P. H. Dixneuf
Chem. Eur. J., 2011, 17, 9456-9462.
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Method for the Preparation of Phenols via Copper-Catalyzed Hydroxylation
of Aromatic Halogenated Compounds.
M. Taillefer, F. Monnier, A. Tlili, N. Xia
PCT Int. Appl. (2010), WO 142913.
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Selective One-pot Access to Symmetrical or Unsymmetrical Diarylethers via
Copper-Catalyzed Double Arylation of a Simple Oxygen Source.
A. Tlili, F. Monnier,* M. Taillefer*
Chem. Eur. J., 2010, 16, 12299.
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Procédé de synthèse de biarylethers.
M. Taillefer, F. Monnier, A. Tlili
FR Patent (2010), 0570099.
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Iron and Copper Catalytic Systems for Cross-Coupling Reactions.
M. Taillefer, F. Monnier, A. Tlili, N. Xia
US Patent (2010), 996830.
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Method for Hydroxylation of Fully Halogenated Compounds.
M. Taillefer, F. Monnier, A. Tlili, N. Xia
FR Patent (2010), 2946339.
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A Very Simple Copper-Catalyzed Synthesis of Phenols Employing Hydroxide Salts.
A. Tlili, N. Xia, F. Monnier,* M. Taillefer*
Angew. Chem., Int. Ed. 2009, 48, 8725-8728.
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Procédé de synthèse de phénols
M. Taillefer, F. Monnier, A. Tlili, N. Xia
FR Patent (2009), FR 02767.
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Catalytic C-C, C-N, and C-O Ullmann-Type Coupling Reactions
F. Monnier,* M. Taillefer*
Angew. Chem., Int. Ed. 2009, 48, 6954-697.
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New Catalytic Systems for Cross-Coupling Reactions.
M. Taillefer, N. Xia, F. Monnier, A. Tlili
PCT Int. Appl. (2009), WO 2009071997 A2 20090611.
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Sol-Gel Immobilized and Reusable Copper-Catalyst for Arylation of Phenols
from Aryl Bromides.
S. Benyahya, F. Monnier,* M. Wong Chi Man,* C. Bied,
F. Ouazzani, M. Taillefer*
Green Chem. 2009, 11, 1121-1123.
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Copper-Catalyzed Sonogashira-Type Reaction Under Palladium-Free Conditions.
F. Monnier,* F. Turtaut, L. Duroure, M. Taillefer*
Org. Lett., 2008, 10, 3203-3206.
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Efficient and Versatile Sol-Gel Immobilized Copper Catalyst for Ullmann
Arylation of Phenols.
S. Benyahya, F. Monnier,* M.Taillefer,* M. Wong Chi Man,*
C. Bied, F.Ouazzani
Adv. Synth. Cat., 2008, 350, 2205.
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Catalytic C-C, C-N and C-O Ullmann-Type Coupling Reactions :
Copper Makes a Difference.
F. Monnier,* M. Taillefer*
Angew. Chem., Int. Ed., 2008, 47, 3096-3099
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Selective Ruthenium-Catalyzed Transformations of Enynes with Diazoalkanes
into Alkenylbicyclo[3.1.0]hexanes.
F. Monnier, C. Vovard-Le Bray, D. Castillo, V. Aubert, S. Dérien, P. H. Dixneuf,*
L. Toupet, A. Ienco, C. Mealli*
J. Am. Chem. Soc., 2007, 129, 6037-6049.
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One-Step Synthesis of Fluorinated Bicyclic Aminoesters via Ruthenium-Catalysed
Tandem alkenylation/Cyclopropanation of Enynes with Diazoalkanes
F. Monnier, M. Eckert, I. Titanyuk, S. Osipov, S. Dérien,* P. H. Dixneuf*
Org. Lett., 2005, 7, 3741-3743.
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Efficient Synthesis of Tris(acetonitrile)-( 5-cyclopentadienyl)-ruthenium(II)
Hexafluoro-phosphate via Ruthenocene.
E. P. Kündig,* F. R. Monnier,
Adv. Synth. Cat., 2004, 346, 8, 901-904.
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Ruthenium-Catalyzed C-C Bond Formation.
S. Dérien,* F. Monnier, P. H. Dixneuf,
Topics in Organometallic Chemistry, Vol. 11, 2004, 1-44.
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Addition of Diazoalkanes to Enynes Promoted by a Ruthenium Catalyst:
Simple Synthesis of Alkenyl Bicyclo[3.1.0]hexane Derivatives.
F. Monnier, D. Castillo, S. Dérien,* L. Toupet, P. H. Dixneuf*
Angew. Chem., Int. Ed., 2003, 42, 5474-5477.
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Biscarbene-Ruthenium Complexes in Catalysis: Novel Stereoselective Synthesis of
(1E,3E)-1,4-Disubstituted-1,3-dienes via Head-to-Head Coupling of Terminal
Alkynes and Addition of Carboxylic Acids.
J. Le Paih, F. Monnier, S. Dérien,* P. H. Dixneuf,* E. Clot, O. Eisenstein*
J. Am. Chem. Soc., 2003, 125, 11964-11975.
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Ruthenium Catalyzed Regioselective Hydrophosphination of Propargyl Alcohols.
F. Jérôme, F. Monnier, H. Lawicka, S. Dérien,* P. H. Dixneuf*
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Ruthenium Acetylide Oxidation: From Stable Radicals to Allenylidene Synthesis via
Elimination of H+
S. Rigaut,* F. Monnier, F. Mousset, D. Touchard,* P. H. Dixneuf
